Rauful Alam, Ph.D.

Rauful Alam, Ph.D.

Drug Discovery Scientist  |  Synthetic Chemist  |  Consultant  |  Author
Staff Scientist, Center for Chemical Biology & Therapeutics, University of Chicago — and core contributor to PTC518 (votoplam), now in Phase III trials for Huntington's disease.

I am a drug discovery scientist with a Ph.D. in Organic Chemistry, working at the intersection of AI, computational science, and experimental chemistry to advance preclinical drug discovery. My work spans synthetic and medicinal chemistry, API development, R&D strategy, and scientific consulting. Beyond the laboratory, I am passionate about teaching, scientific writing, research integrity, and building a stronger culture of education and research in Bangladesh.

Phase III
PTC518 (votoplam) in trials
13
Publications, 7 as lead author
4
Patent families
8 yrs
Drug discovery experience
Trained and worked at
University of Chicago PTC Therapeutics University of Pennsylvania Stockholm University
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About Me

My Journey: From Dawn Light to Discovery

My story begins long before my own journey—on a muddy village road in Bangladesh. My father walked 8 kilometers back and forth every day for five years, from grade 6 through grade 10, just to attend school.

There was no electricity at home, and fuel for a hurricane lamp was a luxury he often could not afford. So, he studied at dawn, chasing knowledge in the dim light of a new day. In 1969, he passed his matriculation exam with Physics, Chemistry, Biology, and Advanced Mathematics. Education transformed his life, and he instilled in me the same belief: that a pen and a dream could change everything.

I didn't walk the same 8 kilometers, but I walked the same road—literally and figuratively—through the footprints he left behind. From a small rural school, I carried my father's dream forward, determined to step onto the global stage.

I completed my higher secondary education at Cumilla Victoria College, earned my undergraduate degree in Chemistry from the University of Chittagong, and then took a leap beyond borders. In Stockholm, Sweden, I pursued my MS and PhD in Organic Chemistry at Stockholm University. That was the beginning of my life as a scientist—one defined by courage, curiosity, and the drive to step outside my comfort zone.

Since then, my path has taken me from academic research in Europe to leadership roles in pharmaceutical innovation in the United States. At PTC Therapeutics, I contributed to advancing treatments for rare diseases, and today, as a Staff Scientist at the University of Chicago's Center for Chemical Biology and Therapeutics, I continue to explore the chemistry of life with a focus on drug discovery.

Beyond the laboratory, I have always believed in the power of knowledge-sharing. For years, I have written in national newspapers and across social media, raising my voice for science, education, and research culture. I have also authored books designed to spark curiosity and make science accessible to young learners. These efforts are tied to a larger dream: to expand STEM education in rural areas, so that children growing up on muddy roads like the one my father once walked can see themselves as future scientists, innovators, and leaders.

In many ways, my story is not just about me—it is about carrying forward a legacy. It is about a boy who once studied by dawn light, and the son who now works to light the way for others—through science, teaching, and the dream of building a stronger research culture in Bangladesh and beyond.

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Legacy of Learning

Inspired by my father's dedication—walking 16km daily for education and studying by dawn light—carrying forward the transformative power of knowledge.

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Global Journey

From rural Bangladesh to Stockholm University (PhD) to leading pharmaceutical roles in the US, embracing courage and curiosity at every step.

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Drug Discovery Impact

Contributing to rare disease treatments at PTC Therapeutics and advancing chemical biology research at the University of Chicago.

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Knowledge Sharing

Writing in national newspapers, social media advocacy for science education, and authoring books to make science accessible to young learners.

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STEM Education Vision

Dream of expanding STEM education in rural areas, ensuring children on muddy roads can envision themselves as future scientists and leaders.

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Building Research Culture

Working to strengthen research culture in Bangladesh and beyond, lighting the way for others through science, teaching, and mentorship.

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API Synthesis & Lab Building

As API manufacturing expands in Bangladesh, the shortage of trained synthetic chemists is the bottleneck. I consult on establishing synthetic laboratories and leading API route design, scale-up, and process development.

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Regulatory & Global Partnerships

Advising on FDA and ICH guideline compliance, quality documentation, and technology transfer—while building international research and industry partnerships that connect Bangladeshi pharma to global standards.

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Professional Journey

September 2025 - Present

Staff Scientist (Medicinal Chemistry)

Center for Chemical Biology and Therapeutics (CCBT), University of Chicago

May 2024 - August 2025

Voluntary Career Break — Independent Research & Professional Development

Resigned by choice to support family relocation · Self-directed work in AI-driven chemistry and intellectual property

September 2023 - May 2024

Principal Scientist

PTC Therapeutics, NJ

March 2020 - August 2023

Senior Scientist

PTC Therapeutics, NJ

April 2018 - February 2020

Scientist-II

PTC Therapeutics, NJ

September 2016 - March 2018

Postdoctoral Research

University of Pennsylvania

Advisor: Prof. Gary A. Molander

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Education

Ongoing Professional Development

Specialist Courses & Training

American Chemical Society · Schrödinger · Drew University

  • Pharmacokinetics for Chemists in Drug Discovery and Development (ACS)
  • Introduction to Molecular Modeling in Drug Discovery (Schrödinger)
  • Drew University Medicinal Chemistry Course (one-week intensive)
  • 19th Drug Discovery Chemistry Conference, April 2024
January 2012 - March 2016

PhD in Organic Chemistry

Stockholm University, Sweden

Advisor: Prof. Kálmán J Szabó

Examiner: Prof. Varinder K. Aggarwal, University of Bristol

August 2009 - May 2011

MS in Organic Chemistry

Stockholm University, Sweden

2008

MSc in Inorganic Chemistry

University of Chittagong, Bangladesh

2006

BSc in Chemistry

University of Chittagong, Bangladesh

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Expertise & Consulting

Eight years of small-molecule drug discovery across industry and academia, built on doctoral and postdoctoral synthetic methodology research — from Stockholm University and the University of Pennsylvania, to a Phase III programme at PTC Therapeutics, to AI-driven screening at the University of Chicago. Below is what that experience lets me deliver for a partner organisation.

Phase III
Core contributor to PTC518 (votoplam) for Huntington's disease
13
Peer-reviewed publications, 7 as lead author
4
Patent families, all highlighted in ACS Med. Chem. Lett.
Ph.D.
Organic Chemistry, Stockholm University

What I Can Do For You

Six areas where I take on consulting, scientific leadership, and collaborative engagements with pharmaceutical companies, universities, and research institutions.

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Drug Discovery Program Leadership

Taking a target from initial assessment through to an optimised lead series.

  • Target assessment with patent and literature landscape analysis
  • Hit identification, triage, and prioritisation strategy
  • SAR-driven lead optimisation and design cycles
  • DMPK and ADME property optimisation planning
  • CRO selection, briefing, and day-to-day scientific management
Medicinal Chemistry SAR Analysis DMPK / ADME Patent Landscaping CRO Management
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AI & Computational Screening

Screening millions of compounds computationally before committing to synthesis.

  • Structure-based virtual screening campaigns at library scale
  • Binding-affinity prediction and computational hit triage
  • Protein structure preparation and molecular docking
  • GPU and HPC pipeline setup, including cost-per-campaign modelling
  • Chemist-reviewed shortlists ready for purchase or synthesis
Boltz-2 DrugCLIP Chemistry42 RowanSci Schrödinger Maestro HPC / Slurm
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API Process Development & Scale-Up

Turning a published or lab-scale route into something a plant can actually run.

  • Synthetic route scouting, selection, and cost analysis
  • Scale-up planning and process optimisation
  • Impurity profiling and reference standard strategy
  • Raw material sourcing and vendor technical assessment
  • Technology transfer packages and process documentation
Process Chemistry Route Scouting Impurity Profiling Scale-Up Tech Transfer
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Laboratory Establishment & Capacity Building

Building a working synthetic laboratory, and the team that can run it.

  • Laboratory layout, workflow design, and equipment specification
  • Instrument procurement guidance and commissioning support
  • Safety, solvent handling, and waste management protocols
  • SOP development and analytical method setup
  • Recruitment support and hands-on training of synthetic chemists
Lab Design Equipment Specification SOPs & Safety Team Training Mentorship
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Regulatory Guidance & Global Partnerships

Aligning local capability with international regulatory expectations.

  • FDA and ICH guideline interpretation for chemistry teams
  • GMP-ready documentation review and gap analysis
  • CMC data package preparation support
  • Academic and industry partnership development across borders
  • Grant, proposal, and technical dossier writing support
FDA & ICH Guidelines GMP Documentation CMC Support Partnership Building Proposal Writing
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Training, Teaching & Scientific Writing

Raising the technical baseline of a team, a department, or a readership.

  • Custom workshops in organic, medicinal, and process chemistry
  • Curriculum design for university and industry training programmes
  • Manuscript, thesis, and technical report editing
  • Research integrity and scientific communication coaching
  • Public science writing and outreach content
Workshop Delivery Curriculum Design Scientific Editing Research Integrity Science Communication

Technical Toolkit

The bench techniques, instrumentation, and software behind the capabilities above.

🧪 Synthesis & Chemistry

Multistep Synthesis Asymmetric Synthesis Photoredox Catalysis Heterocyclic Chemistry Route Optimisation Purification & Chromatography

🔬 Analysis & Characterisation

NMR Spectroscopy HPLC Chiral HPLC & SFC GC-MS HRMS FT-IR Structure Elucidation

💻 Software & Platforms

ChemDraw MNova TopSpin ACD/Spectrus D360 (Dotmatics) BIOVIA Insight DataWarrior GraphPad Prism BioRender ELN & EndNote

Looking for a consultant or scientific collaborator?

I take on advisory engagements, project-based consulting, and long-term scientific leadership roles with pharmaceutical companies, universities, and research institutions. Tell me what you are trying to build and I will tell you honestly whether I am the right person for it.

Start a Conversation
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Publications

Peer-reviewed articles: 13  |  Lead authorship: 7  |  4 patent families

Photoredox-catalyzed Direct Reductive Amination

Alam, R.; Molander, A. G. | Org. Lett. 2018

Novel synthetic methodology for direct reductive amination without external hydrogen/hydride source using photoredox catalysis.

Catalytic Asymmetric Allylboration

Alam, R. et al. | Angew. Chem. Int. Ed. 2016

Stereodivergent synthesis approach enabling construction of up to three contiguous stereocenters using allylboronic acids.

Synthesis of Adjacent Quaternary Stereocenters

Alam, R. et al. | J. Am. Chem. Soc. 2015

Breakthrough methodology for catalytic asymmetric allylboration enabling efficient quaternary stereocenter formation.

Research Presentations
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Research Presentations

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254th ACS National Meeting

August 2017 | Washington, USA

Presented cutting-edge research in photoredox catalysis with both oral and poster presentations. Featured in prestigious Sci-Mix session.

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PACIFICHEM Conference

December 2015 | Hawaii, USA

Delivered oral and poster presentations on novel asymmetric allylboration methodologies at this premier international conference.

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248th ACS National Meeting

August 2014 | San Francisco, USA

Showcased breakthrough research in stereoselective synthesis with oral and poster presentations, including Sci-Mix session.

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Offered Courses

Comprehensive chemistry courses designed to build strong foundations and advance your understanding in organic and medicinal chemistry.

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Fundamentals of Organic Chemistry

Master core principles, reactions, and mechanisms

30h
Duration
10
Weeks
৳10k
Fee

Build a comprehensive understanding of organic chemistry including molecular structure, stereochemistry, reaction mechanisms, and spectroscopic analysis techniques.

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Fundamentals of Medicinal Chemistry

Explore drug design and pharmaceutical development

30h
Duration
10
Weeks
৳10k
Fee

Discover how molecules become medicines through modern drug design principles, pharmacophore identification, SAR analysis, and pharmaceutical development strategies.

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Educational Resources

A curated collection of useful learning websites, chemistry tools, biology resources, AI platforms, literature databases, and productivity tools for students, teachers, researchers, and science enthusiasts.

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Chemistry & Drug Discovery

Useful tools for chemical structures, molecules, proteins, and drug discovery research.

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Molecular Biology & Bioinformatics

Reliable biological databases for genes, proteins, sequences, and structures.

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Learning Platforms

High-quality online platforms for structured learning and self-study.

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AI & Scientific Tools

AI-assisted platforms for learning, writing, coding, and research productivity.

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Scientific Literature

Search engines and publication platforms for scientific papers and references.

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Productivity & Scientific Writing

Helpful tools for writing, reference management, design, and scientific communication.

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Medicinal Chemistry & Drug Development

Practical resources for hit finding, compound sourcing, regulatory look-ups, and staying current with drug discovery.

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Published Books

A collection of published books by Rauful Alam written for curious readers, students, teachers, young learners, and lifelong learners. These books aim to make science, education, national development, and reflective thinking more accessible and engaging.

Book cover: একটা দেশ যেভাবে দাঁড়ায়

একটা দেশ যেভাবে দাঁড়ায়

Author: Rauful Alam • Published: 2019

Published in 2019, this book examines how a nation can move forward by investing in quality education, a strong research culture, and the development of young people. With Bangladesh as the central focus, it discusses how unproductive university cultures, including excessive student and teacher politics, weak talent discovery systems, and insufficient research training, can limit national progress—and why a more merit-based, research-driven educational ecosystem is essential for the country’s future.

Book cover: বাংলাদেশের স্বপ্নচোখ

বাংলাদেশের স্বপ্নচোখ

Author: Rauful Alam • Published: 2021

Published in 2021, this book reflects on Bangladesh’s present realities and future possibilities from political, educational, and innovation-driven perspectives. It explores how the country can build a more thoughtful, creative, and forward-looking society by strengthening institutions, improving education, encouraging research, and nurturing a culture that values ideas, integrity, and long-term national development.

Book cover: The ABC's of Science for Kids

The ABC's of Science for Kids

Author: Rauful Alam

A colorful and interactive science book for children that introduces scientific ideas through the alphabet, from A to Z—for example, “A is for Atom.” Each page combines simple explanations with engaging visuals to support curiosity, cognitive engagement, and early scientific thinking in young readers.

Book cover: নক্ষত্রবীথির গহিনে

নক্ষত্রবীথির গহিনে

Author: Rauful Alam

A popular science book that explores the mysteries of the universe in a simple, engaging, and accessible way. It introduces fascinating ideas about space, stars, galaxies, and the cosmos for readers who are curious about the beauty and wonder of the universe.

Book cover: সফল মন্ত্র

সফল মন্ত্র

Author: Rauful Alam

A thoughtful book on life philosophy that encourages readers to look beyond material success and social expectations. It emphasizes the deeper meaning of life, personal growth, inner fulfillment, and the value of the journey itself rather than defining success only through money, status, or conventional achievements.

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Latest Blog Posts

Short, useful, and research-informed articles on organic chemistry, medicinal chemistry, drug discovery, education, AI-assisted research, and science communication.

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Chemistry Latest

My First Scientific Blog

A short introductory article connecting chemistry, education, research culture, and the habit of writing regularly for students and science learners.

Read Article →
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Archive Ongoing

Essays on Science, Education & Research Culture

A longer-running collection of my writing on scientific research, higher education, and building research capacity — including pieces published in national newspapers.

Visit Archive →
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Video YouTube

Science Talks & Explainers

Recorded lectures, chemistry explainers, and conversations on research careers, aimed at students and early-career scientists.

Watch →
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Get In Touch

I'm always interested in discussing new opportunities, collaborations, and innovative research ideas. Feel free to reach out!

Email Me

Drop me a line for research collaborations, consulting engagements, or professional inquiries.

Academic & Research
rauful@uchicago.edu
Consulting & General
rauful.alam15@gmail.com

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Connect Online

Explore my research, publications, and professional journey through these platforms.

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Professional Location

Chicago, IL, USA

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